Marc Flajolet; Yashoda SUNKARI

WO2024097744A2

Link: https://patents.google.com/patent/WO2024097744A2/en?

Abstract

The present invention provides methods of generating diverse chemical structures on DNA through Wittig olefination of novel on-DNA phosphorane ylides and Homer- Wadsworth-Emmons reaction of on-DNA β-keto phosphonates. The methods of this invention provide access to DNA-encode libraries (DELs) of diverse peptides, peptidomimetics, chalcone-based molecules, and the like.