Yagong Wang , Huanqing Zhang , Fanming Zeng , Xue Zhao , Junyun Chen , Lijun Xue , Kexin Yang , Yun Jin Hu

Chemistry - An Asian Journal

DOI: 10.1002/asia.70611

Abstract

Dithiocarbamates (DTCs) are privileged scaffolds in medicinal chemistry, yet inaccessible via DNA-encoded libraries (DELs) due to a lack of robust on-DNA synthesis. We developed a general procedure for on-DNA DTC formation using a carbon disulfide (CS2) bridging strategy. This method efficiently links diverse aliphatic secondary amines and alkyl halides under mild conditions with high conversions and excellent DNA compatibility. The utility of this method was demonstrated by constructing a prototype DEL, thereby bridging a critical gap in chemical space and facilitating the rapid discovery of DTC-based therapeutics.