Zhaobing Ding, Feifei Li, Jun Lu, Bing Qi

Organic Letters

DOI: 10.1021/acs.orglett.6c01786

Abstract

Here, we report a mild and DNA-compatible cyclization strategy for the construction of [1,2,4]triazolo[1,5-a]pyridine scaffolds that is well suited for DNA-encoded library (DEL) construction. This reaction proceeds via cyclocondensation of aldehydes with 1,2-diaminopyridinium salt substrates under mild and simple conditions. This method enables the rapid and efficient construction of a series of DNA-encoded libraries containing compounds with a potentially biologically active [1,2,4]triazolo[1,5-a]pyridine scaffold.